Edward H Schuchman Selected Research

Acid Ceramidase

1/2021	Acid Ceramidase Protects Against Hepatic Ischemia/Reperfusion Injury by Modulating Sphingolipid Metabolism and Reducing Inflammation and Oxidative Stress.
10/2020	Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
1/2019	Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.
1/2018	Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.
6/2017	Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.
9/2014	Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.
6/2013	Systemic ceramide accumulation leads to severe and varied pathological consequences.
5/2007	Acid ceramidase is a novel factor required for early embryo survival.
8/2003	Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase.
8/2003	The reverse activity of human acid ceramidase.

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Edward H Schuchman Research Topics

Disease

41	Niemann-Pick Diseases (Niemann Pick Disease) 11/2020 - 05/2002
14	Inflammation (Inflammations) 01/2021 - 01/2006
14	Neoplasms (Cancer) 01/2019 - 05/2005
11	Farber Lipogranulomatosis 06/2017 - 02/2002
10	Mucopolysaccharidoses 12/2019 - 05/2005
9	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2021 - 12/2002
9	Alzheimer Disease (Alzheimer's Disease) 12/2020 - 12/2006
8	Type B Niemann-Pick Disease 01/2017 - 12/2002
6	Type A Niemann-Pick Disease 01/2019 - 04/2009
6	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2011 - 05/2007
5	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 11/2020 - 05/2007
5	Infections 10/2020 - 09/2014
5	Inborn Genetic Diseases (Disease, Hereditary) 10/2020 - 05/2007
4	Fibrosis (Cirrhosis) 10/2021 - 01/2010
4	Cystic Fibrosis (Mucoviscidosis) 10/2020 - 09/2014
4	Lung Diseases (Lung Disease) 10/2020 - 01/2010
3	Neuroinflammatory Diseases 01/2022 - 04/2009
3	Insulin Resistance 01/2021 - 09/2009
3	Pneumonia (Pneumonitis) 01/2019 - 03/2003
3	Atherosclerosis 09/2016 - 10/2008
3	Memory Disorders (Memory Loss) 01/2014 - 02/2010
2	Necrosis 01/2021 - 01/2013
2	Reperfusion Injury 01/2021 - 01/2018
2	Neurologic Manifestations (Neurological Manifestations) 12/2019 - 01/2018
2	Gliosis 01/2019 - 10/2007
2	Gaucher Disease (Gaucher's Disease) 01/2017 - 02/2004
2	Mucopolysaccharidosis I (Hurler Syndrome) 01/2016 - 07/2007
2	Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy) 01/2014 - 01/2011
2	Congenital Abnormalities (Deformity) 01/2013 - 01/2011
2	Joint Diseases (Joint Disease) 01/2010 - 01/2008
1	Silicosis 10/2021
1	Poisoning 10/2021
1	Obesity 01/2021
1	Overnutrition 01/2021
1	Mucopolysaccharidosis II (Hunter Syndrome) 12/2019
1	Brain Diseases (Brain Disorder) 01/2019
1	Mucopolysaccharidosis III (Sanfilippo Syndrome) 01/2019
1	Graves Disease (Basedow Disease) 11/2018
1	Graves Ophthalmopathy 11/2018
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018
1	Ischemia 01/2018
1	Ulcerative Colitis 01/2018
1	Bacterial Infections (Bacterial Infection) 06/2017
1	Lymphocytosis 01/2017
1	Splenomegaly 01/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2016
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 10/2016
1	Arthritis (Polyarthritis) 10/2016
1	Dysphonia (Spastic Dysphonia) 10/2016

Drug/Important Bio-Agent (IBA)

43	AcidsIBA 01/2019 - 05/2002
41	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2019 - 05/2002
31	neodymium pyrocatechin disulfonate (NPD)IBA 01/2019 - 05/2002
20	CeramidesIBA 01/2021 - 05/2005
19	EnzymesIBA 10/2020 - 07/2002
18	LipidsIBA 01/2021 - 07/2002
17	SphingolipidsIBA 10/2021 - 04/2009
15	SphingomyelinsIBA 10/2021 - 07/2002
11	Acid CeramidaseIBA 01/2021 - 02/2002
8	SphingosineIBA 12/2020 - 08/2003
6	Proteins (Proteins, Gene)FDA Link 11/2017 - 12/2002
5	Pentosan Sulfuric Polyester (Pentosan Polysulfate)FDA Link 12/2019 - 01/2013
4	CytokinesIBA 01/2019 - 05/2005
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 02/2010
4	GlycosaminoglycansIBA 01/2016 - 05/2005
3	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 11/2018 - 01/2013
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2017 - 01/2006
3	Pharmaceutical PreparationsIBA 06/2015 - 12/2006
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013 - 01/2010
3	HydrolasesIBA 01/2013 - 09/2005
3	Insulin (Novolin)FDA Link 09/2009 - 04/2003
3	Mannose (D-Mannose)IBA 08/2005 - 01/2004
2	Amyloid beta-PeptidesIBA 01/2022 - 02/2010
2	EndocannabinoidsIBA 01/2021 - 11/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 07/2004
2	Lysergic Acid Diethylamide (LSD)IBA 10/2020 - 10/2012
2	Oxygen (Dioxygen)IBA 01/2018 - 08/2013
2	Phenobarbital (Luminal)FDA Link 06/2017 - 09/2014
2	AntibodiesIBA 06/2017 - 05/2013
2	CeramidasesIBA 10/2016 - 02/2002
2	CholesterolIBA 02/2014 - 09/2002
2	plerixafor FDA Link 11/2013 - 07/2011
2	Toll-Like Receptor 4IBA 01/2011 - 01/2010
2	Therapeutic UsesIBA 02/2010 - 01/2010
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2007 - 05/2005
2	Biomarkers (Surrogate Marker)IBA 03/2006 - 05/2005
1	AcetyltransferasesIBA 12/2020
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 12/2020
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 11/2020
1	fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA 11/2020
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 10/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	Long-Acting Thyroid Stimulator (LATS)IBA 11/2018
1	olipudase alfaIBA 01/2018
1	arginyl-glycyl-aspartic acidIBA 06/2017
1	LigandsIBA 06/2017

Therapy/Procedure

12	Therapeutics 12/2019 - 03/2006
8	Enzyme Replacement Therapy 01/2018 - 01/2004
7	Transplantation 01/2018 - 12/2003
2	Injections 10/2012 - 10/2007
1	Hematopoietic Stem Cell Transplantation 01/2017